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Main Sequence

Kingmaker TierBased on the data VC Catalog holds.

Kingmaker Tier: 88 out of 100

Also known as Main Sequence Ventures

  • Advanced manufacturing
  • Agtech
  • AI models & AI infrastructure
  • Biotech & therapeutics
  • Carbon & climate software
  • Care delivery & digital health
  • Clean energy & storage
  • Food production tech
  • Health IT
  • Medical devices & diagnostics
  • Mental health & wellness
  • Robotics & automation
  • Space, aerospace & defense
  • Sustainable materials & circular economy
  • Women's & family health
  • Pre seed
  • Seed
  • Series A
  • Series B
  • AI native
  • Climate positive
  • Deeptech
  • AU
  • VC
  • B2B
Investor type
VC
Investing status
Activeas of 2026-09-17Source (opens in a new tab)
Headquarters
Eveleigh, NSW, Australia
Founded
2017
Legal name
CSIRO Financial Services Pty Ltd
Claim, correct or request removal

Record updated 17 September 2026

About

It takes an unreasonable belief to achieve the impossible. This is what we invest in and create at Main Sequence.

Investment approach

Thesis
We invest in early stage startups (and inventors wishing to create a startup) that have science at their core. We love to work with inventors who have an 'unreasonable belief' that they can solve an impossible challenge.Source (opens in a new tab)
Eligibility
Our investments must have a connection with Australian publicly funded research. This does not need to exist before investment but needs to be part of the investment design. Be ready to articulate how your company does (or could) work with an Australian university or other research group such as CSIRO.
Investing status notes
Fund 3 commenced investment in 2023 and continues to build its investment portfolio, with 16 investments made so far.

Locations

Headquarters
Eveleigh, NSW, Australia

Programs

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